Targeting cardiomyocyte cell death

MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1

To improve regeneration of the injured myocardium, cardiomyocyte progenitor cells (CMPCs) have been put forward as a potential cell source for transplantation therapy. Although cell transplantation therapy displayed promising results, many issues need to be addressed before fully appreciating their impact. One of the hurdles is poor graft-cell survival upon injection, thereby limiting potential...

miR-613 suppresses ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting the programmed cell death 10 gene.

MicroRNAs (miRNAs) are important gene regulators in both biological and pathological processes, including myocardial ischemia/reperfusion (I/R) injury. This study investigated the effect of miR-613 on I/R-induced cardiomyocyte apoptosis and its molecular mechanism of action. Hypoxia/reoxygenation (H/R) significantly increased the release of lactate dehydrogenase (LDH), levels of malondialdehyde...

Targeting the Failing Cardiomyocyte Signalosome

Targeting abnormal calcium (Ca) handling in ventricular cardiomyocytes emerged as a new paradigm for human heart failure (HF) therapy. Cardiomyocytes come with an extensive Ca signaling toolkit consisting of various Ca transporters, Ca channels, Ca buffer, and sensor proteins. Organized into self-contained signaling modules in which Ca signaling functions within highly localized environments, t...

Neuronal death and survival - targeting glutamate-induced cell death mechanisms

Cell Death Induction by Targeting Tumor Metabolism

Over the last century, a broader interest in the topic of tumor metabolism has emerged. From the 1920s onward, when Otto Warburg proposed increased aerobic glycolysis of tu‐ mor cells, a deeper understanding has established that tumor cells have an altered metab‐ olism which is directly linked to cancer progression. It was soon discovered that not only do environmental changes lead to alteratio...